Article
Cell cycle progression is required for zebrafish somite morphogenesis but not segmentation clock function.
Development (Cambridge, England) - 1 Jun 2008
Zhang Lixia, Kendrick Christina, Jülich Dörthe, Holley Scott A
Abstract excerpt
Cell division, differentiation and morphogenesis are coordinated during embryonic development, and frequently are in disarray in pathologies such as cancer. Here, we present a zebrafish mutant that ceases mitosis at the beginning of gastrulation, but that undergoes axis elongation and develops blood, muscle and a beating heart. We identify the mutation as being in early mitotic inhibitor 1 (emi1), a negative...
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