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Article

Notch1 is required for the coordinate segmentation of somites.

Development (Cambridge, England) - 1 May 1995

Conlon R A, Reaume A G, Rossant J

Abstract excerpt

Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half of gestation. In the first half of gestation, we have found no effect of the mutation on the normal programs of...

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Identifiers

PMID: 7789282
DOI: 10.1242/dev.121.5.1533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Notch1 is required for the coordinate segmentation of somites.PMID 7789282Read ↗

Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.Semantic proximity Read ↗

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.Semantic proximity Read ↗

The role of presenilin 1 during somite segmentation.Semantic proximity Read ↗

Role of Delta-like-3 in mammalian somitogenesis and vertebral column formation.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Greb1 is required for axial elongation and segmentation in vertebrate embryos.Semantic proximity Read ↗

Involvement of SIP1 in positioning of somite boundaries in the mouse embryo.Semantic proximity Read ↗

Mesp2 initiates somite segmentation through the Notch signalling pathway.Semantic proximity Read ↗

Notch signalling and the synchronization of the somite segmentation clock.Semantic proximity Read ↗

Cell cycle progression is required for zebrafish somite morphogenesis but not segmentation clock function.Semantic proximity Read ↗

Notchless is required for axial skeleton formation in mice.Semantic proximity Read ↗

Snail1 gene function during early embryo patterning in mice.Semantic proximity Read ↗

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