Article
Notch1 is required for the coordinate segmentation of somites.
Development (Cambridge, England) - 1 May 1995
Conlon R A, Reaume A G, Rossant J
Abstract excerpt
Members of the Notch family of transmembrane receptors mediate a number of developmental decisions in invertebrates. In order to study Notch function in a vertebrate organism, we have mutated the Notch1 gene of the mouse. Notch1 gene function is required for embryonic survival in the second half...
Topics
- Animals
- Apoptosis
- Embryonic Induction
- Gene Expression
- Genotype
- Immunohistochemistry
- In Situ Hybridization
- Membrane Proteins
- Mesoderm
- Mice
- Mice, Transgenic
- Models, Genetic
- Molecular Sequence Data
- Morphogenesis
- Mutagenesis, Site-Directed
- Phenotype
- Receptors, Notch