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Molecular basis of protein S deficiency in China

27 Jun 2013

Abstract excerpt

Protein S (ProS) is a physiological inhibitor of coagulation with an important function in the down-regulation of thrombin generation. ProS deficiency is a major risk factor for venous thrombosis. This study enrolled 40 ProS-deficient probands to investigate the molecular basis of hereditary ProS deficiency in Chinese patients. A mutation analysis was performed by resequencing the PROS1 gene. Large deletions were...

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PMID: 23813890
DOI: 10.1002/ajh.23525

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