Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk.

doi:10.1007/s10552-008-9164-3

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Article

Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk.

Cancer causes & control : CCC - 1 Nov 2008

Hazra Aditi, Fuchs Charles S, Chan Andrew T, Giovannucci Edward L, Hunter David J

Abstract excerpt

We evaluated the association of a polymorphism in TCF7L2 (RS12255372) in the WNT signaling pathway, which previously has been strongly associated with risk of Type II Diabetes, with colorectal cancer (CRC) and adenoma in the prospective Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS) cohorts. Hyperinsulinemia may be related to the risk of colon adenoma and cancer, therefore this variant...

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PMID: 18478343
DOI: 10.1007/s10552-008-9164-3
PMCID: PMC2719293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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