Article
No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.
BMC cancer - 4 Sept 2009
Goode Ellen L, Szabo Csilla, Prokunina-Olsson Ludmila, Vierkant Robert A, Fredericksen Zachary S, Collins Francis S, White Kristin L, Schmidt Michele, Fridley Brooke L, Couch Fergus J
Abstract excerpt
BACKGROUND: TCF7L2 is a transcription factor involved in Wnt/beta-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. METHODS: Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases,...
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