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Article

Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a population-based study.

The Prostate - 15 May 2008

Agalliu Ilir, Suuriniemi Miia, Prokunina-Olsson Ludmila, Johanneson Bo, Collins Francis S, Stanford Janet L, Ostrander Elaine A

Abstract excerpt

BACKGROUND: Transcription factor 7-like 2 (TCF7L2) is a high mobility group-box containing protein that is a critical member of the Wnt/beta-catenin canonical signaling pathway. In addition to its recently recognized role in diabetes, aberrant TCF7L2 expression has been implicated in cancer through regulation of cell proliferation and apoptosis by c-MYC and cyclin D. It has been hypothesized that germline...

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PMID: 18302196
DOI: 10.1002/pros.20732
PMCID: PMC2765224

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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