Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recombinant expression of a type IV, cAMP-specific phosphodiesterase: characterization and structure-function studies of deletion mutants.

Biochemistry - 11 Mar 1997

Kovala T, Sanwal B D, Ball E H

Abstract excerpt

A potential role for cAMP in regulating the differentiation of myoblasts has led us to examine the components of the cAMP signaling system, including the type IV, cAMP-specific phosphodiesterases. The full coding sequence of the phosphodiesterase PDE4D1 was inserted in the bacterial expression vector pGEX-KG. N- and C-terminal truncations were also placed in the same vector, allowing the expression and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cloning, Molecular
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Escherichia coli

Share to Gene Expression

Share to Kinetics

Share to Mutation

Source

Identifiers

PMID: 9062127
DOI: 10.1021/bi9613483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombinant expression of a type IV, cAMP-specific phosphodiesterase: characterization and structure-function studies of deletion mutants.PMID 9062127Read ↗

Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide SignalingSemantic proximity Read ↗

Clinical and Molecular Genetics of the Phosphodiesterases (PDEs)Semantic proximity Read ↗

The intracellular targeting and regulation of PDE4 cyclic AMP-specific phosphodiesterase enzymesSemantic proximity Read ↗

Characterization of a cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum.Semantic proximity Read ↗

Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4.Semantic proximity Read ↗

Overview of PDEs and their regulation.Semantic proximity Read ↗

Functional characteristics and research trends of PDE11A in human diseases (Review).Semantic proximity Read ↗

Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localizationSemantic proximity Read ↗

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2Semantic proximity Read ↗

PDE4DIP in health and diseasesSemantic proximity Read ↗

Identification and analysis of phosphodiesterase isoenzymesSemantic proximity Read ↗

Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.