Article
The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.
Gene - 30 Jul 1993
Obernolte R, Bhakta S, Alvarez R, Bach C, Zuppan P, Mulkins M, Jarnagin K, Shelton E R
Abstract excerpt
Five protein families are needed to encompass the diversity of cyclic-AMP (cAMP) phosphodiesterases (PDE). Family IV PDEs (PDE IV) specifically hydrolyze cAMP with a low Km, and are selectively inhibited by rolipram (Rp) and related drugs. Cloned cDNAs from rat (r) suggest that the PDE IV family...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Alternative Splicing
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Blotting, Northern
- Blotting, Southern
- Cell Line
- DNA, Recombinant
- Escherichia coli
- Genetic Variation
- Humans
- Isoenzymes
- Molecular Sequence Data
- Multigene Family
- Polymerase Chain Reaction