Article
Hepatitis C virus core proteins derived from different quasispecies of genotype 1b inhibit the growth of Chang liver cells.
World journal of gastroenterology - 14 May 2008
Yan Xue-Bing, Mei Lei, Feng Xia, Wan Mei-Rong, Chen Zhi, Pavio Nicole, Brechot Christian
Abstract excerpt
AIM: To investigate the influence of different quasispecies of hepatitis C virus (HCV) genotype 1b core protein on growth of Chang liver cells. METHODS: Three eukaryotic expression plasmids (pEGFP-N1/core) that contained different quasispecies truncated core proteins of HCV genotype 1b were constructed. These were derived from tumor (T) and non-tumor (NT) tissues of a patient infected with HCV and C191 (HCV-J6)....
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