Article
Studies on the role of NS3 and NS5A non-structural genes of hepatitis C virus genotype 3a local isolates in apoptosis.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Aug 2014
Sabri Sabeen, Idrees Muhammad, Rafique Shazia, Ali Amjad, Iqbal Muhammad
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) is the causative agent of chronic liver diseases, which usually lead to liver fibrosis, liver cirrhosis, and hepatocellular carcinoma (HCC). Among the non-structural genes of HCV, NS3 and NS5A play important roles in apoptosis. The NS3 and NS5A genes of HCV interact with the p53 tumor suppressor gene differentially. The objective of this study was to analyze the interaction of...
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