Hepatitis C virus protein expression induces apoptosis in HepG2 cells.

doi:10.1006/viro.2000.0835

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Article

Hepatitis C virus protein expression induces apoptosis in HepG2 cells.

Virology - 30 Mar 2001

Kalkeri G, Khalap N, Garry R F, Fermin C D, Dash S

Abstract excerpt

The mechanisms of hepatocyte death and the events that lead to a high rate of chronic liver disease in patients infected with hepatitis C virus are not known. We established a HCV replication system in HepG2 cell culture and utilized this model to address the effect of HCV proteins on HepG2 cell growth and viability. After transfection of HepG2 cells with full-length RNA, a truncated RNA, or an antisense RNA,...

Topics

Apoptosis
Cell Cycle
Cell Division
Cell Line
Cell Nucleus
Cell Survival
DNA
DNA Fragmentation
Flow Cytometry
Hepacivirus
Humans
In Situ Nick-End Labeling
Microscopy, Electron
Mutation
RNA, Antisense
RNA, Viral
Thymidine
Transfection

Source

Open in PubMed

Identifiers

PMID: 11259187
DOI: 10.1006/viro.2000.0835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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