PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras

Abstract excerpt

<title>Abstract</title> <p>Activation of the Ras signaling pathway promotes the growth of malignant human glioblastoma multiforme (GBM). Mutations in Ras are rare in GBM, elevated levels of activated Ras are prevalently observed in GBM. However, the potential mechanism of how Ras is activated in GBM remains unclear. In this study, we screened a new interacted protein of Ras, PHLDA1. Our findings confirmed that PH...

Topics

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• Apoptosis
• Axon Guidance and Neuronal Signaling
• Cancer Mechanisms and Therapy
• Databases, Factual
• Ferroptosis and cancer prognosis
• Gene Expression Regulation, Neoplastic
• Glioma Diagnosis and Treatment
• Hippo pathway signaling and YAP/TAZ

Identifiers and source

Literature Corpus work

4c277cda-79dc-59b0-8d32-141dc5cb81ee

DOI

10.21203/rs.3.rs-1775642/v1