Article
Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway.
Cancer cell - 1 May 2004
Wang Yan, Engels Ingo H, Knee Deborah A, Nasoff Marc, Deveraux Quinn L, Quon Kim C
Abstract excerpt
The genetic concept of synthetic lethality provides a framework for identifying genotype-selective anticancer agents. In this approach, changes in cellular physiology that arise as a consequence of oncogene activation or tumor suppressor gene loss, rather than oncoproteins themselves, are targeted to achieve tumor selectivity. Here we show that agonists of the TRAIL death receptor DR5 potently induce apoptosis in...
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