Article
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
PLoS genetics - 9 May 2008
Wu Chunlei, Delano David L, Mitro Nico, Su Stephen V, Janes Jeff, McClurg Phillip, Batalov Serge, Welch Genevieve L, Zhang Jie, Orth Anthony P, Walker John R, Glynne Richard J, Cooke Michael P, Takahashi Joseph S, Shimomura Kazuhiro, Kohsaka Akira, Bass Joseph, Saez Enrique, Wiltshire Tim, Su Andrew I
Abstract excerpt
Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene expression levels across genetic mapping populations. These gene expression phenotypes have been used for genome-wide association analyses, an analysis referred to as expression QTL (eQTL) mapping. Here, eQTL analysis was...
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