Article
Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2006
Bao Lei, Wei Lai, Peirce Jeremy L, Homayouni Ramin, Li Hongqiang, Zhou Mi, Chen Hao, Lu Lu, Williams Robert W, Pfeffer Lawrence M, Goldowitz Dan, Cui Yan
Abstract excerpt
Gene expression QTL (eQTL) mapping can suggest candidate regulatory relationships between genes. Recent advances in mammalian phenotype annotation such as mammalian phenotype ontology (MPO) enable systematic analysis of the phenotypic spectrum subserved by many genes. In this study we combined eQTL mapping and phenotypic spectrum analysis to predict gene regulatory relationships. Five pairs of genes with similar...
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