Article
Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma.
International journal of cancer - 15 Jul 2008
Patard Jean-Jacques, Fergelot Patricia, Karakiewicz Pierre I, Klatte Tobias, Trinh Quoc-Dien, Rioux-Leclercq Nathalie, Said Jonathan W, Belldegrun Arie S, Pantuck Allan J
Abstract excerpt
We attempted to describe, in a series of clear cell renal cell carcinoma (RCC), the relationship between CAIX expression, VHL gene mutations, tumor characteristics and outcome. Radical nephrectomy was performed in 100 patients. Genomic DNA was extracted from frozen tumor samples. Four amplimers covering the whole coding sequence of the VHL gene were synthesized by PCR and sequenced. The monoclonal antibody M75...
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