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Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease

7 May 2008

Abstract excerpt

Amelyoid-beta peptide (Abeta) is a major causative agent responsible for Alzheimer's disease (AD). Abeta contains a high affinity metal binding site that modulates peptide aggregation and toxicity. Therefore, identifying molecules targeting this site represents a valid therapeutic strategy. To test this hypothesis, a range of L-PtCl(2) (L = 1,10-phenanthroline derivatives) complexes were examined and shown to...

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PMID: 18463291
DOI: 10.1073/pnas.0800712105

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