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Article

Camptothecin and its analogs reduce amyloid-β production and amyloid-β42-induced IL-1β production.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Wang Ju, Shi Zi-Qi, Zhang Mu, Xin Gui-Zhong, Pang Tao, Zhou Ping, Chen Jun, Qi Lian-Wen, Yang Hua, Xu Xiaojun, Li Ping

Abstract excerpt

Compounds derived from natural products are becoming promising alternative drugs/tools in Alzheimer's disease (AD) therapeutics. From an in-house natural products library, seventeen hits were selected for their inhibitory effect on the production of amyloid-β (Aβ) with IC50 lower than 10 μM without causing obvious toxicity. Among these compounds, camptothecin (CPT) and its analogs showed inhibitory effects on...

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PMID: 25096614
DOI: 10.3233/JAD-140078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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