Correlation of TP53 and MDM2 genotypes and clinical outcome in platinum-treated head and neck cancer patients with more than 10 years' follow-up.

doi:10.5301/jbm.5000192

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Article

Correlation of TP53 and MDM2 genotypes and clinical outcome in platinum-treated head and neck cancer patients with more than 10 years' follow-up.

The International journal of biological markers - 28 May 2016

Vivenza Daniela, Monteverde Martino, Lattanzio Laura, Tonissi Federica, Astesana Valentina, Denaro Nerina, Comino Alberto, Russi Elvio, Lo Nigro Cristiana, Merlano Marco

Abstract excerpt

PURPOSE: Adequate biomarkers are still required to optimize therapy in patients with locally advanced head and neck squamous carcinomas (HNSCC) treated with chemoradiotherapy (CRT). METHODS: We updated the follow-up of 66 HNSCC patients treated with CRT we described more than 10 years ago, focusing on SNP Arg/Pro (R/P) at codon 72 and somatic mutations in TP53 and on SNP309 in the MDM2 gene. RESULTS: In wild-type...

Topics

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Carcinoma, Squamous Cell
Female
Follow-Up Studies
Genotype
Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Mutation, Missense

Neoplasm Staging

Organoplatinum Compounds

Polymorphism, Single Nucleotide

Proto-Oncogene Proteins c-mdm2

Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed

Identifiers

PMID: 26916894
DOI: 10.5301/jbm.5000192

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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