Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

doi:10.1371/journal.pone.0002031

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Article

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

PloS one - 7 May 2008

Cauchi Stéphane, Meyre David, Durand Emmanuelle, Proença Christine, Marre Michel, Hadjadj Samy, Choquet Hélène, De Graeve Franck, Gaget Stefan, Allegaert Frederic, Delplanque Jérôme, Permutt Marshall Alan, Wasson Jon, Blech Ilana, Charpentier Guillaume, Balkau Beverley, Vergnaud Anne-Claire, Czernichow Sébastien, Patsch Wolfgang, Chikri Mohamed, Glaser Benjamin, Sladek Robert, Froguel Philippe

Abstract excerpt

BACKGROUND: Recently, several Genome Wide Association (GWA) studies in populations of European descent have identified and validated novel single nucleotide polymorphisms (SNPs), highly associated with type 2 diabetes (T2D). Our aims were to validate these markers in other European and non-European populations, then to assess their combined effect in a large French study comparing T2D and normal glucose tolerant...

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Identifiers

PMID: 18461161
DOI: 10.1371/journal.pone.0002031
PMCID: PMC2346547

Genes

CDKAL1
IGFBP2
HHEX
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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