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Article

Validation of type 2 diabetes risk variants identified by genome-wide association studies in Han Chinese population: a replication study and meta-analysis.

PloS one - 1 Jan 2014

Chang Yi-Cheng, Liu Pi-Hua, Yu Yu-Hsiang, Kuo Shan-Shan, Chang Tien-Jyun, Jiang Yi-Der, Nong Jiun-Yi, Hwang Juey-Jen, Chuang Lee-Ming

Abstract excerpt

BACKGROUND: Several genome-wide association studies (GWAS) involving European populations have successfully identified risk genetic variants associated with type 2 diabetes mellitus (T2DM). However, the effects conferred by these variants in Han Chinese population have not yet been fully elucidated. METHODS: We analyzed the effects of 24 risk genetic variants with reported associations from European GWAS in 3,040...

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Asian People
Case-Control Studies
Diabetes Mellitus, Type 2
Epistasis, Genetic
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 24736664
DOI: 10.1371/journal.pone.0095045
PMCID: PMC3988150

Genes

CDKAL1
HHEX
EXT2
FTO
JAZF1

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