Article
Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes.
Molecular psychiatry - 1 Sept 2023
Han Seonggyun, DiBlasi Emily, Monson Eric T, Shabalin Andrey, Ferris Elliott, Chen Danli, Fraser Alison, Yu Zhe, Staley Michael, Callor W Brandon, Christensen Erik D, Crockett David K, Li Qingqin S, Willour Virginia, Bakian Amanda V, Keeshin Brooks, Docherty Anna R, Eilbeck Karen, Coon Hilary
Abstract excerpt
Recent large-scale genome-wide association studies (GWAS) have started to identify potential genetic risk loci associated with risk of suicide; however, a large portion of suicide-associated genetic factors affecting gene expression remain elusive. Dysregulated gene expression, not assessed by GWAS, may play a significant role in increasing the risk of suicide death. We performed the first comprehensive genomic...
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