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Article

Functional DNA methylation in a transcript specific 3'UTR region of TrkB associates with suicide.

Epigenetics - 1 Aug 2014

Maussion Gilles, Yang Jennie, Suderman Matthew, Diallo Alpha, Nagy Corina, Arnovitz Mitchell, Mechawar Naguib, Turecki Gustavo

Abstract excerpt

Previous studies indicate that a subgroup of suicide completers has low cortical brain expression levels of TrkB-T1, a TrkB gene transcript that is highly expressed in astrocytes. Epigenetic modifications, including methylation changes in the TrkB promoter, partially explain TrkB-T1 low expression levels in brain tissue from suicide completers. The aim of this study was to investigate whether methylation changes...

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Identifiers

PMID: 24802768
DOI: 10.4161/epi.29068
PMCID: PMC4164491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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