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Increased DNA methylation in the suicide brain

30 Sept 2014

Abstract excerpt

Clinical studies find that childhood adversity and stressful life events in adulthood increase the risk for major depression and for suicide. The predispositions to either major depression or suicide are thought to depend on genetic risk factors or epigenetic effects. We investigated DNA methylation signatures postmortem in brains of suicides with diagnosis of major depressive disorder. DNA methylation levels...

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PMID: 25364291
DOI: 10.31887/dcns.2014.16.3/jmann

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