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Differential Allelic Expression of HTR1B in Suicide Victims: Genetic and Epigenetic Effect of the Cis-Acting Variants.

Neuropsychobiology - 1 Jan 2016

Bani-Fatemi Ali, Howe Aaron, Zai Clement, Kennedy James L, Vincent John, Strauss John, Wong Albert, De Luca Vincenzo

Abstract excerpt

OBJECTIVES: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. METHODS: The study was conducted using 3 sets of samples. First, C861G allele-specific mRNA levels in the frontal cortex were compared between suicide (n = 13) and nonsuicide controls (n = 13) from the Stanley Medical Research postmortem brain...

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PMID: 28445878
DOI: 10.1159/000456010

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