Increased BDNF promoter methylation in the Wernicke area of suicide subjects.

doi:10.1001/archgenpsychiatry.2010.9

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Increased BDNF promoter methylation in the Wernicke area of suicide subjects.

Archives of general psychiatry - 1 Mar 2010

Keller Simona, Sarchiapone Marco, Zarrilli Federica, Videtic Alja, Ferraro Angelo, Carli Vladimir, Sacchetti Silvana, Lembo Francesca, Angiolillo Antonella, Jovanovic Nikolina, Pisanti Francesco, Tomaiuolo Rossella, Monticelli Antonella, Balazic Joze, Roy Alec, Marusic Andrej, Cocozza Sergio, Fusco Alfredo, Bruni Carmelo B, Castaldo Giuseppe, Chiariotti Lorenzo

Abstract excerpt

CONTEXT: Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the pathophysiology of suicidal behavior and BDNF levels are decreased in the brain and plasma of suicide subjects. So far, the mechanisms leading to downregulation of BDNF expression are poorly understood. OBJECTIVES: To test the hypothesis that alterations of DNA methylation could be involved in the dysregulation of BDNF gene expression...

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PMID: 20194826
DOI: 10.1001/archgenpsychiatry.2010.9

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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