Article
Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991
Chumakov K M, Powers L B, Noonan K E, Roninson I B, Levenbook I S
Abstract excerpt
Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous neurovirulence safety testing of each vaccine lot, currently carried out in monkeys. It has been reported that a change from 472-U to 472-C in the type 3 OPV RNA is associated with an increased histologic lesion scor...
Topics
- Animal Testing Alternatives
- Animals
- Base Sequence
- Cell Line
- Chlorocebus aethiops
- Haplorhini
- Kidney
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Poliovirus
- Poliovirus Vaccine, Oral
- Polymerase Chain Reaction
- RNA, Viral
- Vaccines, Attenuated