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Article

Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991

Chumakov K M, Powers L B, Noonan K E, Roninson I B, Levenbook I S

Abstract excerpt

Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous neurovirulence safety testing of each vaccine lot, currently carried out in monkeys. It has been reported that a change from 472-U to 472-C in the type 3 OPV RNA is associated with an increased histologic lesion score produced upon intraspinal inoculation of the mutant virus in monkeys. We have developed a method, based on polymerase...

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Identifiers

PMID: 1846038
DOI: 10.1073/pnas.88.1.199
PMCID: PMC50777

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