Article
(GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course.
Clinical and experimental immunology - 1 Jul 2008
Hausmann M, Paul G, Kellermeier S, Frey I, Schölmerich J, Falk W, Menzel K, Fried M, Herfarth H, Rogler G
Abstract excerpt
Haem oxygenase-1 (HO-1) up-regulation was suggested to reduce mucosal tissue damage in inflammatory bowel disease (IBD) and an up-regulation of HO-1 expression in patients with Crohn's disease (CD) and ulcerative colitis (UC) was demonstrated. A HO-1 gene promoter microsatellite (GT)(n) dinucleotide repeat polymorphism was associated with regulation of HO-1 in response to inflammatory stimuli. We therefore...
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