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Article

Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm.

Thrombosis research - 15 Apr 2002

Schillinger Martin, Exner Markus, Mlekusch Wolfgang, Domanovits Hans, Huber Kurt, Mannhalter Christine, Wagner Oswald, Minar Erich

Abstract excerpt

OBJECTIVE: Vascular inflammation is a hallmark in the development of abdominal aortic aneurysms (AAA). Heme oxygenase-1 (HO-1) is a novel vascular anti-inflammatory factor. A (GT)(n) dinucleotide repeat in the HO-1 gene promoter shows a length polymorphism that modulates the level of gene transcription. Short (< 25 GT) repeats are associated with an increased HO-1 upregulation in response to inflammatory stimuli...

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Source

Identifiers

PMID: 12182912
DOI: 10.1016/s0049-3848(02)00100-7

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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