Article
HO-1 promoter polymorphism associated with rheumatoid arthritis.
Arthritis and rheumatism - 1 Dec 2007
Rueda Blanca, Oliver Javier, Robledo Gema, López-Nevot Miguel A, Balsa Alejandro, Pascual-Salcedo Dora, González-Gay Miguel A, González-Escribano Maria F, Martín Javier
Abstract excerpt
OBJECTIVE: To investigate the role of the HO-1 gene as a novel functional candidate gene for rheumatoid arthritis (RA). METHODS: We performed a case-control study including 736 RA patients and 846 healthy controls of Spanish Caucasian origin. Two putative functional HO-1 promoter polymorphisms, a (GT)(n) microsatellite and a -413 A/T single-nucleotide polymorphism (SNP), were selected as genetic markers and...
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