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Article

HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis.

Arthritis and rheumatism - 1 Nov 2008

Wagener Frank A D T G, Toonen Erik J M, Wigman Lonneke, Fransen Jaap, Creemers Marjonne C W, Radstake Timothy R D J, Coenen Marieke J H, Barrera Pilar, van Riel Piet L C M, Russel Frans G M

Abstract excerpt

OBJECTIVE: The guanine-thymidine (GT)n repeat in the HMOX1 promoter determines the level of induction of the heme-degrading enzyme heme oxygenase 1 (HO-1), which protects against inflammatory and oxidative stress. In individuals with short (GT)n repeats (where n < 25; SS genotype), higher levels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18975324
DOI: 10.1002/art.23970

Genes

HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18975324-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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