Article
Overexpression of Myostatin2 in zebrafish reduces the expression of dystrophin associated protein complex (DAPC) which leads to muscle dystrophy.
Journal of biomedical science - 1 Sept 2008
Amali Aseervatham Anusha, Lin Cliff Ji-Fan, Chen Yi-Hsuan, Wang Wei-Lun, Gong Hong-Yi, Rekha Ravikumar Deepa, Lu Jenn-Kan, Chen Thomas T, Wu Jen-Leih
Abstract excerpt
Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle and growth. Previously, we reported Mstn1 from zebrafish and studied its influence on muscle development. In this study, we identified another form of Myostatin protein which is referred to as Mstn2. The size of Mstn2 cDNA is 1342 bp with 109 and 132 bp of 5' and 3'-untranslated regions (UTRs), respectively. The...
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