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Article

Induction of p53-Independent Apoptosis by Simian Virus 40 Small t Antigen

1 Oct 2001

Abstract excerpt

Simian virus 40 small t antigen (st) is required for optimal transformation and replication properties of the virus. We find that in certain cell types, such as the human osteosarcoma cell line U2OS, st is capable of inducing apoptosis, as evidenced by a fragmented nuclear morphology and positive terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling staining of transfected cells. The cell death can...

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PMID: 11533178
DOI: 10.1128/jvi.75.19.9142-9155.2001

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