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The VirB System Plays a Crucial Role in Brucella Intracellular Infection

20 Dec 2021

Abstract excerpt

Brucellosis is a highly prevalent zoonotic disease caused by Brucella. Brucella spp. are gram-negative facultative intracellular parasitic bacteria. Its intracellular survival and replication depend on a functional virB system, an operon encoded by VirB1–VirB12. Type IV secretion system (T4SS) encoded by the virB operon is an important virulence factor of Brucella. It can subvert cellular pathway and induce host...

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PMID: 34948430
DOI: 10.3390/ijms222413637

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