Article
Comparative proteomics analyses reveal the virB of B. melitensis affects expression of intracellular survival related proteins.
PloS one - 1 Jan 2009
Wang Yufei, Chen Zeliang, Qiao Feng, Ying Tianyi, Yuan Jing, Zhong Zhijun, Zhou Lei, Du Xinying, Wang Zhoujia, Zhao Jin, Dong Shicun, Jia Leili, Yuan Xitong, Yang Ruifu, Sun Yansong, Huang Liuyu
Abstract excerpt
BACKGROUND: Brucella melitensis is a facultative, intracellular, pathogenic bacterium that replicates within macrophages. The type IV secretion system encoded by the virB operon (virB) is involved in Brucella intracellular survival. However, the underlying molecular mechanisms, especially the target proteins affected by the virB, remain largely unclear. METHODOLOGY/PRINCIPAL FINDINGS: In order to define the...
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