Article
The two-component system BvrR/BvrS regulates the expression of the type IV secretion system VirB in Brucella abortus.
Journal of bacteriology - 1 Nov 2010
Martínez-Núñez Carola, Altamirano-Silva Pamela, Alvarado-Guillén Francisco, Moreno Edgardo, Guzmán-Verri Caterina, Chaves-Olarte Esteban
Abstract excerpt
The pathogenesis of Brucella is related to the ability to multiply intracellularly, an event controlled by the two-component system BvrR/BvrS (TCS BvrRS) and the type IV secretion machinery VirB (T4SS VirB). We have hypothesized that the TCS BvrRS transcriptionally regulates the T4SS VirB. To test this hypothesis, we have compared the levels of VirB proteins in the wild-type strain Brucella abortus 2308 and...
Topics
- Bacterial Proteins
- Brucella abortus
- Cell Proliferation
- Gene Expression Regulation, Bacterial
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- RNA, Messenger
- Transcription Factors
- Transcription, Genetic