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Article

D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking.

Pharmacology, biochemistry, and behavior - 1 Sept 2008

Helms C M, Gubner N R, Wilhelm C J, Mitchell S H, Grandy D K

Abstract excerpt

Alleles of the human dopamine D(4) receptor (D(4)R) gene (DRD4.7) have repeatedly been found to correlate with novelty seeking, substance abuse, pathological gambling, and attention-deficit hyperactivity disorder (ADHD). If these various psychopathologies are a result of attenuated D(4)R-mediated signaling, mice lacking D(4)Rs (D(4)KO) should be more impulsive than wild-type (WT) mice and exhibit more novelty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18456309
DOI: 10.1016/j.pbb.2008.03.013
PMCID: PMC2603181

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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