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Article

Revealing a compulsive phenotype in cholinergic M4-/- mice depends on the inter-trial interval initiation settings in a five choice serial reaction time task.

Behavioural brain research - 1 Jul 2020

Justinussen Jessica, Dall Camilla, Dencker Ditte, Gjedde Albert, Fink-Jensen Anders, Thomsen Morgane

Abstract excerpt

BACKGROUND: Muscarinic acetylcholine receptor 4 (M4) modulates dopaminergic neurotransmission and is a target for novel treatments of schizophrenia, cognitive deficits, and addiction. Impulsive and compulsive behaviors are key traits of addiction, yet the importance of M4 receptor signaling to these traits is poorly understood. We investigated impulsive action and compulsivity by measuring premature and...

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Identifiers

PMID: 32344038
DOI: 10.1016/j.bbr.2020.112649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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