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Article

The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding.

Behavioural brain research - 12 Sept 2011

Young Jared W, Powell Susan B, Scott Christine N, Zhou Xianjin, Geyer Mark A

Abstract excerpt

Impairments in attention/vigilance and response disinhibition are commonly observed in several neuropsychiatric disorders. Validating animal models could help in developing therapeutics for cognitive deficits and improving functional outcomes in such disorders. The 5-choice continuous performance test (5C-CPT) in mice offers the opportunity to assess vigilance and two forms of impulsivity. Since reduced dopamine...

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Source

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Identifiers

PMID: 21458500
DOI: 10.1016/j.bbr.2011.03.054
PMCID: PMC3531561

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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