Article
RSF governs silent chromatin formation via histone H2Av replacement.
PLoS genetics - 29 Feb 2008
Hanai Kazuma, Furuhashi Hirofumi, Yamamoto Takashi, Akasaka Koji, Hirose Susumu
Abstract excerpt
Human remodeling and spacing factor (RSF) consists of a heterodimer of Rsf-1 and hSNF2H, a counterpart of Drosophila ISWI. RSF possesses not only chromatin remodeling activity but also chromatin assembly activity in vitro. While no other single factor can execute the same activities as RSF, the biological significance of RSF remained unknown. To investigate the in vivo function of RSF, we generated a mutant...
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