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Article

ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.

Science (New York, N.Y.) - 16 Jan 2004

Mizuguchi Gaku, Shen Xuetong, Landry Joe, Wu Wei-Hua, Sen Subhojit, Wu Carl

Abstract excerpt

The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently...

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Identifiers

PMID: 14645854
DOI: 10.1126/science.1090701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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