Article
Histone H2A.Z regulats transcription and is partially redundant with nucleosome remodeling complexes.
Cell - 27 Oct 2000
Santisteban M S, Kalashnikova T, Smith M M
Abstract excerpt
Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. Mutations in the major core histones relieve transcriptional repression and bypass the requirement for SNF/SWI and SAGA. We have found that the variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases...
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