Article
The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicals.
PLoS genetics - 29 Feb 2008
Kanazawa Takayuki, Zappaterra Mauro D, Hasegawa Ayako, Wright Ashley P, Newman-Smith Erin D, Buttle Karolyn F, McDonald Kent, Mannella Carmen A, van der Bliek Alexander M
Abstract excerpt
The C. elegans eat-3 gene encodes a mitochondrial dynamin family member homologous to Opa1 in humans and Mgm1 in yeast. We find that mutations in the C. elegans eat-3 locus cause mitochondria to fragment in agreement with the mutant phenotypes observed in yeast and mammalian cells. Electron microscopy shows that the matrices of fragmented mitochondria in eat-3 mutants are divided by inner membrane septae,...
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