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Article

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.

Molecular cell - 22 Aug 2008

Breckenridge David G, Kang Byung-Ho, Kokel David, Mitani Shohei, Staehelin L Andrew, Xue Ding

Abstract excerpt

The dynamin family of GTPases regulate mitochondrial fission and fusion processes and have been implicated in controlling the release of caspase activators from mitochondria during apoptosis. Here we report that profusion genes fzo-1 and eat-3 or the profission gene drp-1 are not required for apoptosis activation in C. elegans. However, minor proapoptotic roles for drp-1 and fis-2, a homolog of human Fis1, are...

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Identifiers

PMID: 18722182
DOI: 10.1016/j.molcel.2008.07.015
PMCID: PMC2548325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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