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Article

Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans.

The Journal of biological chemistry - 7 May 2004

Fujii Michihiko, Matsumoto Yuki, Tanaka Nanae, Miki Kensuke, Suzuki Toshikazu, Ishii Naoaki, Ayusawa Dai

Abstract excerpt

The relationship between oxidative stress and longevity is a matter of concern in various organisms. We isolated mutants resistant to paraquat from nematode Caenorhabditis elegans. One mutant named mev-4 was long-lived and showed cross-resistance to heat and Dyf phenotype (defective in dye filling). Genetic and sequence analysis revealed that mev-4 had a nonsense mutation on the che-11 gene, homologues of which...

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PMID: 14982934
DOI: 10.1074/jbc.M313119200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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