DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.

doi:10.1038/nature03316

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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.

Nature - 17 Feb 2005

Jagasia Ravi, Grote Phillip, Westermann Benedikt, Conradt Barbara

Abstract excerpt

Genetic analyses in Caenorhabditis elegans have been instrumental in the elucidation of the central cell-death machinery, which is conserved from C. elegans to mammals. One possible difference that has emerged is the role of mitochondria. By releasing cytochrome c, mitochondria are involved in the activation of caspases in mammals. However, there has previously been no evidence that mitochondria are involved in...

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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.

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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.

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