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Diverse effect of MC4R risk alleles on obesity-related traits over a lifetime: Evidence from a well-designed cohort study.

Gene - 10 Jan 2022

Moazzam-Jazi Maryam, Sadat Zahedi Asiyeh, Akbarzadeh Mahdi, Azizi Fereidoun, Daneshpour Maryam S

Abstract excerpt

This population-based longitudinal study is the first investigation that assesses the association of common MC4R SNPs with the obesity-related parameters over time and determines the effect of risk alleles during the three adulthood life periods (early, middle, and late) in a large Iranian cohort, a population with a unique genetic make-up that has been understudied and relatively unexplored. We obtained the...

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Body Mass Index
Iran
Longitudinal Studies
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Obesity

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Receptor, Melanocortin, Type 4

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PMID: 34481003
DOI: 10.1016/j.gene.2021.145950

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