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Article

GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis.

Blood - 17 Aug 2017

Katayama Saori, Suzuki Mikiko, Yamaoka Ayaka, Keleku-Lukwete Nadine, Katsuoka Fumiki, Otsuki Akihito, Kure Shigeo, Engel James Douglas, Yamamoto Masayuki

Abstract excerpt

Chromosomal rearrangements between 3q21 and 3q26 induce inappropriate EVI1 expression by recruiting a GATA2-distal hematopoietic enhancer (G2DHE) to the proximity of the EVI1 gene, leading to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The acquisition of G2DHE by the EVI1 gene reciprocally deprives this enhancer of 1 of the 2 GATA2 alleles, resulting in a loss-of-function genetic reduction in...

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Identifiers

PMID: 28630119
DOI: 10.1182/blood-2016-12-756767

Genes

GATA2

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