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Article

Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 2010

Dickstein Jerome, Senyuk Vitalyi, Premanand Kavitha, Laricchia-Robbio Leopoldo, Xu Peng, Cattaneo Francesca, Fazzina Raffaella, Nucifora Giuseppina

Abstract excerpt

By expressing EVI1 in murine bone marrow (BM), we previously described a myelodysplastic syndrome (MDS) model characterized by pancytopenia, dysmegakaryopoiesis, dyserythropoiesis, and BM failure. The mice invariably died 11-14 months after BM transplantation (BMT). Here, we show that a double po...

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Identifiers

PMID: 20448201
DOI: 10.1073/pnas.1004297107
PMCID: PMC2906858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20448201-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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