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Article

Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus.

Rheumatology international - 1 Oct 2013

Tahmasebi Zahra, Akbarian Mahmoud, Mirkazemi Sedigheh, Shahlaee Abtin, Alizadeh Zahra, Amirzargar Ali Akbar, Jamshidi Ahmad Reza, Ghoroghi Shima, Poursani Shiva, Nourijelyani Keramat, Mahmoudi Mahdi

Abstract excerpt

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology with a complex pathogenesis involving multiple genetic and environmental contributions. Single-nucleotide polymorphisms (SNPs) in cytokine genes are associated with higher or lower cytokine activity, which can alter the susceptibility to certain diseases or their clinical outcomes. We investigated SNPs of the IL-1 family in...

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PMID: 23722873
DOI: 10.1007/s00296-013-2784-2

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